c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)N1C(NCCC1)=O)C(F)(F)F m15_11 4.5 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)N1C(CCC1)=O)C(F)(F)F m15_12a 4.5 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)N1C(CCC1)=O)F m15_12b 26 c1ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)N1C(CCC1)=O m15_12c 6.4 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)N1C(CCC1)=O)F m15_12d 9.7 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1)Cl)N1C(CCC1)=O)C(F)(F)F m15_12e 11 c1ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1)Cl)N1C(CCC1)=O m15_12f 38 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1)Cl)N1C(CCC1)=O)C(F)(F)F m15_13 8.8 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)N)C(F)(F)F m15_6 39 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)C)F m15_r10a 6 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CN)F m15_r10b 7.1 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CCN)F m15_r10c 2.3 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CCN)C(F)(F)F m15_r7c 10 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)C)F m15_r8a 26 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)C)C(F)(F)F m15_r9a 47 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CN)C(F)(F)F m15_r9b 49 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CCN)C(F)(F)F m15_r9c 29 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)C)F m15_s10a 7.5 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CN)F m15_s10b 3.3 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CCN)F m15_s10c 0.8 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)C)C(F)(F)F m15_s7a 1.8 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CN)C(F)(F)F m15_s7b 1.8 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CCN)C(F)(F)F m15_s7c 1 c1(ccc(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)C1CCNCC1)C(F)(F)F m15_s7d 0.8 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CN)C(F)(F)F m15_s9b 3.3 c1cc(c(c(c1)C(CC(C)C)N)N1CCN(CC1)C(=O)C(Cc1ccc(cc1Cl)Cl)NC(=O)CCN)C(F)(F)F m15_s9c 2.5 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)OC m17_14 520 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN m17_15 4800 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C=O m17_16 1150 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(C(C)C)N)C m17_17 12 c1cc(c(c(c1)F)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(C(C)C)N m17_18 21 c1(cc(c(c(c1)F)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)N)C(F)(F)F m17_19 26 c1cc(c(cc1)N1CCN(CC1)C(=O)C(Cc1ccc(cc1)Cl)NC(C1NCc2c(C1)cccc2)=O)OC m17_2 1100 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN m17_20a 1100 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CNS(=O)(=O)C m17_20b 1700 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)Cn1ccnc1 m17_22a 220 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)Cn1ccnc1C m17_22b 280 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)Cn1c(cnc1)C m17_22c 250 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)Cn1cnnc1 m17_22d 580 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)Cn1ncnc1 m17_22e 320 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)Cn1nncc1 m17_22f 420 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)Cn1cccn1 m17_22g 490 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN(C)C m17_23a 1200 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN(CC)CC m17_23b 1200 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN(CC(C)C)CC(C)C m17_23c 1100 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN(CCOC)C m17_23d 320 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN1CCCC1 m17_23e 550 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN1CCCCC1 m17_23f 950 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN1CCNCC1 m17_23g 360 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN1CCN(CC1)C m17_23h 840 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN1CCC(CC1)N m17_23i 92 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CNCC(C)C m17_24a 510 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CNCCN m17_24b 230 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CNCCNC m17_24c 270 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CNC1CNC1 m17_24d 520 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN(C1CNC1)C m17_24e 240 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CC1CCNCC1 m17_24f 190 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CNc1cccnc1 m17_24g 1600 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CNc1cccnc1N m17_24h 1400 c1cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)CN(CC(C)C)C(=O)CCN m17_25 450 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(C(C)C)N(C)C)C m17_26 13 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(C(C)C)NC(=O)C)C m17_27a 47 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(C(C)C)NC(=O)CN(C)C)C m17_27b 7.1 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(C(C)C)NC(=O)CCN(C)C)C m17_27c 4.7 c1cc(c(c(c1)F)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(C(C)C)NC(=O)CNC m17_28a 11 c1cc(c(c(c1)F)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(C(C)C)NC(=O)C(N)C m17_28b 4.4 c1cc(c(c(c1)F)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(C(C)C)NC(=O)CCN m17_28c 13 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)NC(=O)CN)C(F)(F)F m17_29a 8.9 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)NC(=O)CNC)C(F)(F)F m17_29b 7.7 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)NC(=O)CN(C)C)C(F)(F)F m17_29c 17.3 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)NC(=O)C(N)C)C(F)(F)F m17_29d 4.9 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)NC(=O)C(N)C)C(F)(F)F m17_29e 47 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)NC(=O)CCN)C(F)(F)F m17_29f 8.7 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)NC(=O)CCN(C)C)C(F)(F)F m17_29g 10 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)NC(=O)CC1CNC1)C(F)(F)F m17_29h 18 c1cc(c(cc1)N1CCN(CC1)C(=O)C(Cc1ccc(cc1)Cl)NC(C1NCc2c(C1)cccc2)=O)NS(=O)(=O)C m17_3 250 c1(cc(c(cc1)N1CCN(CC1)C(=O)C1C(CN(C1)C(C)C)c1ccc(cc1)Cl)C(CC(C)C)NS(=O)(=O)C)C(F)(F)F m17_30 87 c1cc(c(cc1)N1CCN(CC1)C(=O)C(Cc1ccc(cc1)Cl)NC(C1NCc2c(C1)cccc2)=O)CN(C)C m17_5 60 c1cc(c(cc1)N1CCN(CC1)C(=O)C(Cc1ccc(cc1)Cl)NC(C1NCc2c(C1)cccc2)=O)C(NC1CCCNC1)C m17_6 6.4 c1(cc(c(cc1)N1CCN(CC1)C(=O)CCc1ccc(cc1Cl)Cl)C(N)C)C(F)(F)F m17_7 490 c1(cc(c(cc1)N1CCN(CC1)C(=O)CCc1ccc(cc1Cl)Cl)C(N)CC(C)C)C(F)(F)F m17_8 74